In vitro silencing of the insulin receptor attenuates cellular accumulation of fibronectin in renal mesangial cells.

ABSTRACT:

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Background

Insulin receptor (InsR) and insulin signaling proteins are widely distributed throughout the kidney cortex. Insulin signaling can act in the kidney in multiple ways, some of which may be totally independent of its primary role of the maintenance of whole-body glucose homeostasis. However, descriptions of the insulin signaling in renal glomerular mesangial cells (MCs) are quite limited and the roles of insulin signaling in MC functions have not been sufficiently elucidated.

Results

InsR silencing induced a unique phenotype of reduced fibronectin (FN) accumulation in renal glomerular MCs. Transcription level of FN was not significantly changed in the InsR silenced cells, suggesting the phenotype switching was caused by post-transcriptional modific

SUBMITTER: Yano N 

PROVIDER: S-EPMC3507851 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature