Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.

ABSTRACT:

Objective

We sought to comprehensively evaluate the association of laminin gamma-1 (LAMC1) and advance pelvic organ prolapse.

Study design

We conducted a candidate gene association of patients (n = 239) with stages III-IV prolapse and controls (n = 197) with stages 0-I prolapse. We used a linkage disequilibrium (LD)-tagged approach to identify single-nucleotide polymorphisms (SNPs) in LAMC1 and focused on non-Hispanic white women to minimize population stratification. Additive and dominant multivariable logistic regression models were used to test for association between individual SNPs and advanced prolapse.

Results

Fourteen SNPs representing 99% coverage of LAMC1 were genotyped. There was no association between SNP rs10911193 and advanced prolapse (P = .34). However

SUBMITTER: Wu JM 

PROVIDER: S-EPMC3508006 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature