DNA-based delivery vehicles: pH-controlled disassembly and cargo release.

ABSTRACT: Non-Watson-Crick base pairing provides an in situ approach for actuation of DNA nanostructures through responses to solution conditions. Here we demonstrate this concept by using physiologically-relevant changes in pH to regulate DNA pyramid assembly/disassembly and to control the release of protein cargo.

SUBMITTER: Keum JW 

PROVIDER: S-EPMC3508031 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature