Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity.

ABSTRACT:

Objective

Quantitative assessment of disease activity in rheumatoid arthritis (RA) is important for patient management, and additional objective information may aid rheumatologists in clinical decision making. We validated a recently developed multibiomarker disease activity (MBDA) test relative to clinical disease activity in diverse RA cohorts.

Methods

Serum samples were obtained from the Index for Rheumatoid Arthritis Measurement, Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study, and Leiden Early Arthritis Clinic cohorts. Levels of 12 biomarkers were measured and combined according to a prespecified algorithm to generate the composite MBDA score. The relationship of the MBDA score to clinical disease activity was characterized separately in seropositive

SUBMITTER: Curtis JR 

PROVIDER: S-EPMC3508159 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature