Expedient synthesis of norbenzomorphan library via multicomponent assembly process coupled with ring-closing reactions.

ABSTRACT: A 124-member norbenzomorphan library has been prepared utilizing a novel multicomponent assembly process (MCAP) followed by a variety of ring-closing reactions to generate norbenzomorphan scaffolds that were readily derivatized via a series of aryl halide cross-coupling and nitrogen functionalization reactions. Biological screening has revealed some novel activities that have not been previously associated with this class of compounds.

SUBMITTER: Sahn JJ 

PROVIDER: S-EPMC3508166 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature