Ontology highlight
ABSTRACT:
SUBMITTER: Castellano S
PROVIDER: S-EPMC3508294 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20121102 22
Arginine methylation is a common post-translational modification that is crucial in modulating gene expression at multiple critical levels. The arginine methyltransferases (PRMTs) are envisaged as promising druggable targets, but their role in physiological and pathological pathways is far from being clear due to the limited number of modulators reported to date. In this effort, enzyme activators can be invaluable tools useful as gain-of-function reagents to interrogate the biological roles in c ...[more]