Functional repertoire, molecular pathways and diseases associated with 3D domain swapping in the human proteome.

ABSTRACT:

Unlabelled

Background

3D domain swapping is a novel structural phenomenon observed in diverse set of protein structures in oligomeric conformations. A distinct structural feature, where structural segments in a protein dimer or higher oligomer were shared between two or more chains of a protein structure, characterizes 3D domain swapping. 3D domain swapping was observed as a key mediator of numerous functional mechanisms and play pathogenic role in various diseases including conformational diseases like amyloidosis, Alzheimer's disease, Parkinson's disease and prion diseases. We report the first study with a focus on identifying functional classes, pathways and diseases mediated by 3D domain swapping in the human proteome.

Methods

We used a panel of four enrichment t

SUBMITTER: Shameer K 

PROVIDER: S-EPMC3508620 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature