Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment.

ABSTRACT:

Aim

To identify hepatitis B virus polymerase gene mutations during antiviral therapy using lamivudine-adefovir sequential monotherapy followed by lamivudine-adefovir combination therapy.

Methods

The patient cohort included four adult chronic hepatitis B patients who had undergone sequential monotherapy, first with lamivudine (LMV) and then, after developing viral breakthrough, with adefovir (ADV) therapy. All of the patients had non-response or viral breakthrough after LMV-ADV sequential monotherapy, which resulted in the switching of their antiviral regimen to LMV-ADV combination therapy. Eleven serum samples from the four patients who showed non-response to rescue LMV-ADV combination therapy were collected sequentially at a time before the antiviral treatment and then duri

SUBMITTER: Ko SY 

PROVIDER: S-EPMC3508638 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature