Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer.

ABSTRACT: Mitotic regulatory pathways insure proper timing of mitotic entry, sister chromatid cohesion and separation, and cytokinesis. Disruption of this process results in inappropriate chromosome segregation and aneuploidy, and appears to contribute to cancer. Specifically, disregulation and somatic mutation of mitotic regulators has been observed in human cancers, and overexpression of mitotic regulators is common in aggressive and late stage tumors. However, the role of germline variation in mitotic pathways and risk of cancer is not well understood. We tested 1,084 haplotype-tagging and functional variants from 164 genes in mitotic regulatory pathways in 791 Caucasian women with breast cancer and 843 healthy controls for association with risk of overall and high grade breast cancer. Sixty-one

SUBMITTER: Stevens KN 

PROVIDER: S-EPMC3508696 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature