An atlas of DNA methylomes in porcine adipose and muscle tissues.

ABSTRACT: It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct skeletal muscle tissues from three pig breeds living within comparable environments but displaying distinct fat level. We generate 1,381 Gb of sequence data from 180 methylated DNA immunoprecipitation libraries, and provide a genome-wide DNA methylation map as well as a gene expression map for adipose and muscle studies. The analysis shows global similarity and difference among breeds, sexes and anato

SUBMITTER: Li M 

PROVIDER: S-EPMC3508711 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature