Structural basis of single molecular heparin-FX06 interaction revealed by SPM measurements and molecular simulations.

ABSTRACT: Heparin, a functionalized polysaccharide, is observed under a scanning tunneling microscope, which shows atomic scale conformational details. The peptide FX06 is found to bind to five consecutive sugar units of heparin and this interaction is directly revealed by atomic force microscopy and dynamic force spectroscopy measurements. The determined free energy change agrees well with the dynamic calculation result.

SUBMITTER: Guo C 

PROVIDER: S-EPMC3508726 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature