Toward an integration of cognitive and genetic models of risk for depression.

ABSTRACT: There is growing interest in integrating cognitive and genetic models of depression risk. We review two ways in which these models can be meaningfully integrated. First, information-processing biases may represent intermediate phenotypes for specific genetic influences. These genetic influences may represent main effects on specific cognitive processes or may moderate the impact of environmental influences on information-processing biases. Second, cognitive and genetic influences may combine to increase reactivity to environmental stressors, increasing risk for depression in a gene×cognition×environment model of risk. There is now growing support for both of these ways of integrating cognitive and genetic models of depression risk. Specifically, there is support for genetic influences on i

SUBMITTER: Gibb BE 

PROVIDER: S-EPMC3509244 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature