Impact of lifestyle intervention and metformin on health-related quality of life: the diabetes prevention program randomized trial.

ABSTRACT:

Background

Adults at high risk for diabetes may have reduced health-related quality of life (HRQoL).

Objective

To assess changes in HRQoL after interventions aimed at diabetes risk reduction.

Design, setting, and participants

A randomized clinical trial, the Diabetes Prevention Program, was conducted in 27 centers in the United States, in 3,234 non-diabetic persons with elevated fasting and post-load plasma glucose, mean age 51 years, mean BMI 34 Kg/m(2); 68 % women, and 45 % members of minority groups.

Interventions

Intensive lifestyle (ILS) program with the goals of at least 7 % weight loss and 150 min of physical activity per week, metformin (MET) 850 mg twice daily, or placebo (PLB).

Measurements

HRQoL using the 36-Item Short-Form (SF-36) health surv

SUBMITTER: Florez H 

PROVIDER: S-EPMC3509296 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature