Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells.

ABSTRACT: Cannabinoids are powerful modulators of inhibition, yet the precise spike timing of cannabinoid receptor (CB1R)-expressing inhibitory neurons in relation to other neurons in the circuit is poorly understood. Here we found that the spike timing of CB1R-expressing basket cells, a major target for cannabinoids in the rat hippocampus, was distinct from the other main group of basket cells, the CB1R-negative. Despite receiving the same afferent inputs, the synaptic and biophysical properties of the two cell types were tuned to detect different features of activity. CB1R-negative basket cells responded reliably and immediately to subtle and repetitive excitation. In contrast, CB1R-positive basket cells responded later and did not follow repetitive activity, but were better suited to integrate th

SUBMITTER: Glickfeld LL 

PROVIDER: S-EPMC3509385 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature