Transcriptional response of mucoid Pseudomonas aeruginosa to human respiratory mucus.

ABSTRACT:

Unlabelled

Adaptation of bacterial pathogens to a host can lead to the selection and accumulation of specific mutations in their genomes with profound effects on the overall physiology and virulence of the organisms. The opportunistic pathogen Pseudomonas aeruginosa is capable of colonizing the respiratory tract of individuals with cystic fibrosis (CF), where it undergoes evolution to optimize survival as a persistent chronic human colonizer. The transcriptome of a host-adapted, alginate-overproducing isolate from a CF patient was determined following growth of the bacteria in the presence of human respiratory mucus. This stable mucoid strain responded to a number of regulatory inputs from the mucus, resulting in an unexpected repression of alginate production. Mucus in the medium

SUBMITTER: Cattoir V 

PROVIDER: S-EPMC3509433 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature