DNTP Supply Gene Expression Patterns after P53 Loss.
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ABSTRACT:
SUBMITTER: Radivoyevitch T
PROVIDER: S-EPMC3509543 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
dNTP Supply Gene Expression Patterns after P53 Loss.
Radivoyevitch Tomas T Saunthararajah Yogen Y Pink John J Ferris Gina G Lent Ian I Jackson Mark M Junk Damian D Kunos Charles A CA
Cancers 20121101 4
Loss of the transcription factor p53 implies mRNA losses of target genes such as the p53R2 subunit of human ribonucleotide reductase (RNR). We hypothesized that other genes in the dNTP supply system would compensate for such p53R2 losses and looked for this in our own data and in data of the Gene Expression Omnibus (GEO). We found that the de novo dNTP supply system compensates for p53R2 losses with increases in RNR subunit R1, R2, or both. We also found compensatory increases in cytosolic deoxy ...[more]
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