Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.

ABSTRACT:

Purpose

This study investigated the anti-tumour effects of the novel vascular disrupting agent plinabulin (NPI-2358) when given alone or combined with radiation.

Materials and methods

Foot implanted C3H mammary carcinomas or leg implanted KHT sarcomas were used, with plinabulin injected intraperitoneally. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measurements were made with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) on a 7-tesla magnet. Treatment response was assessed using regrowth delay (C3H tumours), clonogenic survival (KHT sarcomas) or histological estimates of necrosis for both models.

Results

Plinabulin (7.5 mg/kg) significantly reduced the initial area under curve (IAUC) and the transfer constant (K(trans)) within 1 hour afte

SUBMITTER: Bertelsen LB 

PROVIDER: S-EPMC3509771 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature