Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is a Gram-negative pathogenic bacterium which is resistant to most currently available antibiotics and that poses a significant health threat to hospital patients. LpxA is a key enzyme in the biosynthetic pathway of the lipopolysaccharides that are components of the bacterial outer membrane. It is a potential target for antibacterial agents that might be used to fight A. baumannii infections. This paper describes the structure determination of the apo form of LpxA in space groups P2(1)2(1)2(1) and P6(3). These crystal forms contained three and one protein molecules in the asymmetric unit and diffracted to 1.8 and 1.4 Å resolution, respectively. A comparison of the conformations of the independent protein monomers within and between the two crystal asymmetric units r

SUBMITTER: Badger J 

PROVIDER: S-EPMC3509968 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature