A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation.

ABSTRACT:

Background

The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried out an EST survey of E. granulosus larval stages. We report the salient features of this study with a focus on genes reflecting physiological adaptations of different parasite stages.

Methodology/principal findings

We generated ~10,000 ESTs from two sets of full-length enriched libraries (derived from oligo-capped and trans-spliced cDNAs) prepared with three parasite materials: hydatid cyst wall, larval worms (protoscoleces), and pepsin/H(+)-activated protoscolec

SUBMITTER: Parkinson J 

PROVIDER: S-EPMC3510090 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature