The flavonoid isoquercitrin promotes neurite elongation by reducing RhoA activity.

ABSTRACT:

Background

Neurite formation and synaptic patterning are fundamental to the development of a functional nervous system. Flavonoids are natural molecules known for having beneficial effects on brain health through diverse molecular pathways. Cytoskeletal changes occurring during neuritogenesis and synapse formation often involve Rho GTPases. Here we hypothesized that the flavonoid isoquercitrin promotes neuronal differentiation through Rho signalling.

Methodology/principal findings

We performed time lapse imaging of NG108-15 cells during incubation with/without isoquercitrin. Isoquercitrin stimulated extensive neurites enriched in the synaptic vesicle protein synaptotagmin-1. Neurite extension was augmented by the ROCK inhibitor Y-27632 suggesting an inactivation of RhoA/Rho

SUBMITTER: Palazzolo G 

PROVIDER: S-EPMC3510166 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature