Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions.

ABSTRACT: The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to thousands of genomic loci and activates a cell-type specific gene program. Prostate cancer growth and progression depend on androgen-induced AR signaling. Treatment of advanced prostate cancer through medical or surgical castration leads to initial response and durable remission, but resistance inevitably develops. In castration-resistant prostate cancer (CRPC), AR activity remains critical for tumor growth despite androgen deprivation. Although previous studies have focused on ligand-dependent AR signaling, in this study we explore AR function under the androgen-deprived conditions characteristic of CRPC. Our data demonstrate that AR p

SUBMITTER: Decker KF 

PROVIDER: S-EPMC3510497 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature