SLiMPrints: conservation-based discovery of functional motif fingerprints in intrinsically disordered protein regions.

ABSTRACT: Large portions of higher eukaryotic proteomes are intrinsically disordered, and abundant evidence suggests that these unstructured regions of proteins are rich in regulatory interaction interfaces. A major class of disordered interaction interfaces are the compact and degenerate modules known as short linear motifs (SLiMs). As a result of the difficulties associated with the experimental identification and validation of SLiMs, our understanding of these modules is limited, advocating the use of computational methods to focus experimental discovery. This article evaluates the use of evolutionary conservation as a discriminatory technique for motif discovery. A statistical framework is introduced to assess the significance of relatively conserved residues, quantifying the likelihood a residu

SUBMITTER: Davey NE 

PROVIDER: S-EPMC3510515 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature