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Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes.

ABSTRACT: Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory.

SUBMITTER: Rodrigues J 

PROVIDER: S-EPMC3510677 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes.

Rodrigues Janneth J   Brayner Fábio André FA   Alves Luiz Carlos LC   Dixit Rajnikant R   Barillas-Mury Carolina C  

Science (New York, N.Y.) 20100901 5997

Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocyt  ...[more]

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