The identification of candidate genes and SNP markers for classical bovine spongiform encephalopathy susceptibility.

ABSTRACT: Classical bovine spongiform encephalopathy is a transmissible prion disease that is fatal to cattle and is a human health risk due to its association with a strain of Creutzfeldt-Jakob disease (vCJD). Mutations to the coding region of the prion gene (PRNP) have been associated with susceptibility to transmissible spongiform encephalopathies in mammals including bovines and humans. Additional loci such as the retinoic acid receptor beta (RARB) and stathmin like 2 (STMN2) have also been associated with disease risk. The objective of this study was to refine previously identified regions associated with BSE susceptibility and to identify positional candidate genes and genetic variation that may be involved with the progression of classical BSE. The samples included 739 samples of either BSE i

SUBMITTER: Thomson JM 

PROVIDER: S-EPMC3510855 | biostudies-literature | 2012 Nov-Dec

REPOSITORIES: biostudies-literature