The secreted Alzheimer-related amyloid precursor protein fragment has an essential role in C. elegans.

ABSTRACT: Mutations in the gene encoding the amyloid precursor protein (APP) or the enzymes that process APP are correlated with familial Alzheimer disease. Alzheimer disease is also associated with insulin resistance (type 2 diabetes). In our recently published study, ( 1) we obtained genetic evidence that the extracellular fragment of APL-1, the C. elegans ortholog of human APP, may act as a signaling molecule to modulate insulin and nuclear hormone pathways in C. elegans development. In addition, independent of insulin and nuclear hormone signaling, high levels of the extracellular fragment of APL-1 (sAPL-1) leads to a temperature-sensitive embryonic lethality, which is dependent on activity of a predicted receptor protein tyrosine phosphatase (MOA-1/R155.2). Furthermore, this embryonic lethalit

SUBMITTER: Ewald CY 

PROVIDER: S-EPMC3510856 | biostudies-literature | 2012 Nov-Dec

REPOSITORIES: biostudies-literature