Tigecycline challenge triggers sRNA production in Salmonella enterica serovar Typhimurium.

ABSTRACT:

Background

Bacteria employ complex transcriptional networks involving multiple genes in response to stress, which is not limited to gene and protein networks but now includes small RNAs (sRNAs). These regulatory RNA molecules are increasingly shown to be able to initiate regulatory cascades and modulate the expression of multiple genes that are involved in or required for survival under environmental challenge. Despite mounting evidence for the importance of sRNAs in stress response, their role upon antibiotic exposure remains unknown. In this study, we sought to determine firstly, whether differential expression of sRNAs occurs upon antibiotic exposure and secondly, whether these sRNAs could be attributed to microbial tolerance to antibiotics.

Results

A small scale sRNA clo

SUBMITTER: Yu J 

PROVIDER: S-EPMC3511261 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature