Accurate diagnostics for Bovine tuberculosis based on high-throughput sequencing.

ABSTRACT:

Background

Bovine tuberculosis (bTB) is an enduring contagious disease of cattle that has caused substantial losses to the global livestock industry. Despite large-scale eradication efforts, bTB continues to persist. Current bTB tests rely on the measurement of immune responses in vivo (skin tests), and in vitro (bovine interferon-γ release assay). Recent developments are characterized by interrogating the expression of an increasing number of genes that participate in the immune response. Currently used assays have the disadvantages of limited sensitivity and specificity, which may lead to incomplete eradication of bTB. Moreover, bTB that reemerges from wild disease reservoirs requires early and reliable diagnostics to prevent further spread. In this work, we use high-throughput s

SUBMITTER: Churbanov A 

PROVIDER: S-EPMC3511461 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature