Genealogy-based methods for inference of historical recombination and gene flow and their application in Saccharomyces cerevisiae.

ABSTRACT: Genetic exchange between isolated populations, or introgression between species, serves as a key source of novel genetic material on which natural selection can act. While detecting historical gene flow from DNA sequence data is of much interest, many existing methods can be limited by requirements for deep population genomic sampling. In this paper, we develop a scalable genealogy-based method to detect candidate signatures of gene flow into a given population when the source of the alleles is unknown. Our method does not require sequenced samples from the source population, provided that the alleles have not reached fixation in the sampled recipient population. The method utilizes recent advances in algorithms for the efficient reconstruction of ancestral recombination graphs, which enco

SUBMITTER: Jenkins PA 

PROVIDER: S-EPMC3511476 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature