Cellular functions of genetically imprinted genes in human and mouse as annotated in the gene ontology.

ABSTRACT: By analyzing the cellular functions of genetically imprinted genes as annotated in the Gene Ontology for human and mouse, we found that imprinted genes are often involved in developmental, transport and regulatory processes. In the human, paternally expressed genes are enriched in GO terms related to the development of organs and of anatomical structures. In the mouse, maternally expressed genes regulate cation transport as well as G-protein signaling processes. Furthermore, we investigated if imprinted genes are regulated by common transcription factors. We identified 25 TF families that showed an enrichment of binding sites in the set of imprinted genes in human and 40 TF families in mouse. In general, maternally and paternally expressed genes are not regulated by different transcription

SUBMITTER: Hamed M 

PROVIDER: S-EPMC3511506 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature