Genome context as a predictive tool for identifying regulatory targets of the TetR family transcriptional regulators.

ABSTRACT: TetR family transcriptional regulators (TFRs) are found in most bacteria and archea. Most of the family members that have been investigated to date are repressors of their target genes, and the majority of these, like the well-characterized protein TetR, regulate genes that encode transmembrane efflux pumps. In many cases repression by TFR proteins is reversed through the direct binding of a small-molecule ligand. The number of TFRs in the public database has grown rapidly as a result of genome sequencing and there are now thousands of family members; however virtually nothing is known about the biology and biochemistry they regulate. Generally applicable methods for predicting their regulatory targets would assist efforts to characterize the family. Here, we investigate chromosomal contex

SUBMITTER: Ahn SK 

PROVIDER: S-EPMC3511530 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature