Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers.

ABSTRACT: Circulating 25-hydroxyvitamin D (25-OHD) levels vary among human populations. Only limited information regarding determinants of these measures is available for infants and children, particularly in minority groups at greatest risk for vitamin D deficiency. We identified demographic determinants of circulating 25-OHD in a large cohort of minority children, and now extend our studies to examine potential roles of vitamin D binding protein (DBP) as a determinant of 25-OHD levels. Serum DBP level and common single nucleotide polymorphisms (SNPs) at positions 432 and 436 in the GC gene, encoding DBP, were examined. We confirmed self-reported ancestry using ancestry informative markers (AIMs), and included quantitative AIMs scores in the analysis. The multivariate model incorporated previously

SUBMITTER: Carpenter TO 

PROVIDER: S-EPMC3511814 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature