Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction.

ABSTRACT:

Rationale

Ischemic cardiovascular disease represents one of the largest epidemics currently facing the aging population. Current literature has illustrated the efficacy of autologous, stem cell therapies as novel strategies for treating these disorders. The CD34+ hematopoetic stem cell has shown significant promise in addressing myocardial ischemia by promoting angiogenesis that helps preserve the functionality of ischemic myocardium. Unfortunately, both viability and angiogenic quality of autologous CD34+ cells decline with advanced age and diminished cardiovascular health.

Objective

To offset age- and health-related angiogenic declines in CD34+ cells, we explored whether the therapeutic efficacy of human CD34+ cells could be enhanced by augmenting their secretion of the kn

SUBMITTER: Mackie AR 

PROVIDER: S-EPMC3511820 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature