Aggregation of multiple sclerosis genetic risk variants in multiple and single case families.

ABSTRACT:

Objective

Multiple sclerosis (MS) is a multifactorial neurologic disease characterized by modest but tractable heritability. Genome-wide association studies have identified and/or validated multiple polymorphisms in approximately 16 genes associated with susceptibility. We aimed at investigating the aggregation of genetic MS risk markers in individuals by comparing multiple- and single-case families.

Methods

A weighted log-additive integrative approach termed MS genetic burden (MSGB) was used to account for the well-established genetic variants from previous association studies and meta-analyses. The corresponding genetic burden and its transmission was analyzed in 1,213 independent MS families (810 sporadic and 403 multicase families).

Results

MSGB analysis demonstra

SUBMITTER: Gourraud PA 

PROVIDER: S-EPMC3511846 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature