Influence of prenatal iron deficiency and MAOA genotype on response to social challenge in rhesus monkey infants.

ABSTRACT: Social and emotional behaviors are known to be sensitive to both developmental iron deficiency (ID) and monoamine oxidase A (MAOA) gene polymorphisms. In this study, male rhesus monkey infants deprived of dietary iron in utero were compared with iron sufficient (IS) controls (n = 10/group). Half of each group had low MAOA activity genotypes and half had high MAOA activity genotypes. A series of social response tests were conducted at 3-14 months of age. MAOA genotype influenced attention to a video of aggressive behavior, emotional expression (fear, grimace and sniff) in the social intruder test, social actions (displacement, grooming) in the social dyad test, and aggressive responses to a threatening picture. Interactions between MAOA and prenatal ID were seen in response to the aggressiv

SUBMITTER: Golub MS 

PROVIDER: S-EPMC3511847 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature