Atypical manifestations and poor outcome of herpes simplex encephalitis in the immunocompromised.

ABSTRACT:

Objective

To characterize clinical features, neuroimaging, and outcomes of herpes simplex encephalitis (HSE) in immunocompromised individuals.

Methods

We performed a retrospective case control review of patients diagnosed with HSE. Adult patients were dichotomized into immunocompromised (n = 14) and immunocompetent groups (n = 15).

Results

Fewer immunocompromised patients presented with prodromal symptoms and focal deficits. While the majority of CSF profiles in the immunocompromised patients were mononuclear cells predominant, 3 had polymorphonuclear predominance and another 3 had normal profiles. MRI showed widespread cortical involvement, with brainstem or cerebellar involvement in some. Two immunocompromised patients had recurrent HSE. The immunosuppressed state w

SUBMITTER: Tan IL 

PROVIDER: S-EPMC3511927 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature