Trade-off between selection for dosage compensation and masculinization on the avian Z chromosome.

ABSTRACT: Following the suppression of recombination, gene expression levels decline on the sex-limited chromosome, and this can lead to selection for dosage compensation in the heterogametic sex to rebalance average expression from the X or Z chromosome with average autosomal expression. At the same time, due to their unequal pattern of inheritance in males and females, the sex chromosomes are subject to unbalanced sex-specific selection, which contributes to a nonrandom distribution of sex-biased genes compared to the remainder of the genome. These two forces act against each other, and the relative importance of each is currently unclear. The Gallus gallus Z chromosome provides a useful opportunity to study the importance and trade-offs between sex-specific selection and dosage compensation in sh

SUBMITTER: Wright AE 

PROVIDER: S-EPMC3512148 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature