Local ancestry corrects for population structure in Saccharomyces cerevisiae genome-wide association studies.

ABSTRACT: Genome-wide association studies (GWAS) have become an important method for mapping the genetic loci underlying complex phenotypic traits in many species. A crucial issue when performing GWAS is to control for the underlying population structure because not doing so can lead to spurious associations. Population structure is a particularly important issue in nonhuman species since it is often difficult to control for population structure during the study design phase, requiring population structure to be corrected statistically after the data have been collected. It has not yet been established if GWAS is a feasible approach in Saccharomyces cerevisiae, an important model organism and agricultural species. We thus performed an empirical study of statistical methods for controlling for popula

SUBMITTER: Diao L 

PROVIDER: S-EPMC3512155 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature