Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.

ABSTRACT:

Objective

To investigate the contribution of biomarkers of glucose homeostasis (adiponectin, glucose, glycated albumin, and insulin levels) and inflammation (high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A(2) levels) to the risk of developing Alzheimer disease (AD) and all-cause dementia.

Design

Prospective cohort study.

Setting

Dementia-free Framingham Heart Study participants had sera measured for these biomarkers at the 19th biennial examination (1985-1988) and were followed up prospectively for the development of AD and all-cause dementia.

Participants

Eight hundred forty (541 women, median age of 76 years) subjects participated in the study.

Main outcome measures

We used sex-pooled and sex-specific multivariable Cox pr

SUBMITTER: van Himbergen TM 

PROVIDER: S-EPMC3512190 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature