Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial.

ABSTRACT:

Context

Previous studies have found that few chronically depressed patients remit with antidepressant medications alone.

Objective

To determine the role of adjunctive psychotherapy in the treatment of chronically depressed patients with less than complete response to an initial medication trial.

Design

This trial compared 12 weeks of (1) continued pharmacotherapy and augmentation with cognitive behavioral analysis system of psychotherapy (CBASP), (2) continued pharmacotherapy and augmentation with brief supportive psychotherapy (BSP), and (3) continued optimized pharmacotherapy (MEDS) alone. We hypothesized that adding CBASP would produce higher rates of response and remission than adding BSP or continuing MEDS alone.

Setting

Eight academic sites.

Participan

SUBMITTER: Kocsis JH 

PROVIDER: S-EPMC3512199 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature