Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population.

ABSTRACT:

Background

Musical abilities such as recognising music and singing performance serve as means for communication and are instruments in sexual selection. Specific regions of the brain have been found to be activated by musical stimuli, but these have rarely been extended to the discovery of genes and molecules associated with musical ability.

Methods

A total of 1008 individuals from 73 families were enrolled and a pitch-production accuracy test was applied to determine musical ability. To identify genetic loci and variants that contribute to musical ability, we conducted family-based linkage and association analyses, and incorporated the results with data from exome sequencing and array comparative genomic hybridisation analyses.

Results

We found significant evidence o

SUBMITTER: Park H 

PROVIDER: S-EPMC3512346 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature