24 Common and Rare Variation in the T Helper 2 Gene Pathway Predicts Allergic Asthma Phenotypes

ABSTRACT:

Background

The T helper 2 (Th2) inflammatory pathway, including the Th2-activating cytokine interleukin 33 and its receptor interleukin 1 receptor-like 1 have been strongly implicated in asthma susceptibility (Moffatt MF, et al NEJM 2010). However, the role of Th2 pathway genetic variation in asthma progression and severity is not well understood. Our research group recently developed a clustering algorithm based on comprehensive phenotype information to assign subjects with asthma in the Severe Asthma Research Program (SARP) to 5 primary clusters; 3 of which represent increasing severe allergic asthma (Moore WC, et al AJRCCM, 2010). We hypothesized that common and potentially deleterious rare variation in this pathway would be associated with severe asthma based on SARP cluster d

SUBMITTER: Slager R 

PROVIDER: S-EPMC3512652 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature