116 Genome-Wide Association Studies of Asthma Indicate Opposite Immunopathogenesis Direction From Autoimmune Diseases

ABSTRACT:

Background

Genome-wide association studies (GWAS) of asthma and asthma-related traits, including our previous TENOR study1, have consistently identified ORMDL3-GSDMB, IL33, IL1RL1-IL18R1, RAD50-IL13, TSLP-WDR36, and HLA-DR/DQ regions.2

Methods

In this study, GWAS of asthma was performed in non-Hispanic white population from STAMPEED study (813 cases and 1564 controls). Our GWAS results were compared with the published GWAS of asthma and autoimmune diseases (AD).

Results

Multiple SNPs in TNFAIP3 interacting protein 1 (TNIP1) on chromosome 5q32-q33.1 were associated with asthma in STAMPEED: rs1422673 (P = 3.44 × 10−7) and rs10036748 (P = 1.41 × 10−6). rs1422673 was weakly associated with asthma in the published GABRIEL study (P = 0.018 for meta-analysis)2 but not i

SUBMITTER: Li X 

PROVIDER: S-EPMC3513027 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature