Clinical application of high throughput molecular screening techniques for pharmacogenomics.

ABSTRACT: Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples. Increasing demand for genetic information may necessitate the use of high throughput diagnostic methods as part of clinically validated testing. Here we provide a general overview of our current and near-future abilities to perform large-scale genetic testing in the clinical laboratory. First we review in detail molecular methods used for high throughput mutation detection, including techniques able to monitor thousands of genetic variants for a single patient or to genotype a single genetic variant for thousands of patients simultaneously. These methods are analy

SUBMITTER: Wiita AP 

PROVIDER: S-EPMC3513223 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature