Circulating vitamin D metabolites and kidney disease in type 1 diabetes.

ABSTRACT:

Context

Impaired vitamin D metabolism may contribute to the development and progression of diabetic kidney disease.

Objective

The aim of the study was to test associations of circulating vitamin D metabolites with risks of incident microalbuminuria, impaired glomerular filtration rate (GFR), and hypertension in type 1 diabetes.

Design

We performed a cohort study of 1193 participants in the Diabetes Control and Complications Trial (DCCT), a randomized clinical trial of intensive diabetes therapy, and its observational follow-up, the Epidemiology of Diabetes Interventions and Complications (EDIC) Study. We measured plasma concentrations of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D by mass spectrometry at the end of the DCCT and

SUBMITTER: de Boer IH 

PROVIDER: S-EPMC3513544 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature