Hesperetin: an inhibitor of the transforming growth factor-β (TGF-β) signaling pathway.

ABSTRACT: We have identified a previously unknown function of the natural compound, hesperetin. Here, we demonstrate that this small molecular agent is able to inhibit the transforming growth factor-β (TGF-β) signaling pathway. Single-molecule force measurements and single-molecule fluorescence imaging show that hesperetin interferes with ligand-receptor interactions. Furthermore, by Western blot analysis, it was confirmed that hesperetin also inhibits the phosphorylation of Smad3, a down-stream target of the TGF-β pathway. In addition we demonstrated that this compound hinders TGF-β1-induced cancer cell migration and invasion. These results suggest a potential future application for hesperetin as a TGF-β inhibitor in cancer therapy.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC3513570 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature