Transcriptional analysis of Schistosoma mansoni treated with praziquantel in vitro.

ABSTRACT: Schistosomiasis is one of the foremost health problems in developing countries and has been estimated to account for the loss of up to 56 million annual disability-adjusted life years. Control of the disease relies almost exclusively on praziquantel (PZQ) but this drug does not kill juvenile worms during the early stages of infection or prevent post-treatment reinfection. As the use of PZQ continues to grow, there are fears that drug resistance may become problematic thus there is a need to develop a new generation of more broadly effective anti-schistosomal drugs, a task that will be made easier by having an understanding of why PZQ kills sexually mature worms but fails to kill juveniles. Here, we describe the exposure of mixed-sex juvenile and sexually mature male and female Schistosoma

SUBMITTER: Hines-Kay J 

PROVIDER: S-EPMC3513576 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature