Cardiac electrophysiological imaging systems scalable for high-throughput drug testing.

ABSTRACT: Multi-parametric electrophysiological measurements using optical methods have become a highly valued standard in cardiac research. Most published optical mapping systems are expensive and complex. Although some applications demand high-cost components and complex designs, many can be tackled with simpler solutions. Here, we describe (1) a camera-based voltage and calcium imaging system using a single 'economy' electron-multiplying charge-coupled device camera and demonstrate the possibility of using a consumer camera for imaging calcium transients of the heart, and (2) a photodiode-based voltage and calcium high temporal resolution measurement system using single-element photodiodes and an optical fibre. High-throughput drug testing represents an application where system scalability is par

SUBMITTER: Lee P 

PROVIDER: S-EPMC3513599 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature