Comparison of distribution- and anchor-based approaches to infer changes in health-related quality of life of prostate cancer survivors.

ABSTRACT:

Objective

To determine the minimal important difference (MID) in generic and prostate-specific health-related quality of life (HRQoL) using distribution- and anchor-based methods.

Study design and setting

Prospective cohort study of 602 newly diagnosed prostate cancer patients recruited from an urban academic hospital and a Veterans Administration hospital. Participants completed generic (SF-36) and prostate-specific HRQoL surveys at baseline and at 3, 6, 12, and 24 months posttreatment. Anchor-based and distribution-based methods were used to develop MID estimates. We compared the proportion of participants returning to baseline based on MID estimates from the two methods.

Results

MID estimates derived from combining distribution- and anchor-based methods for the SF-

SUBMITTER: Jayadevappa R 

PROVIDER: S-EPMC3513611 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature