Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia.

ABSTRACT:

Objective

In schizophrenia, alterations within the prefrontal cortical GABA system appear to be most prominent in neurons that contain parvalbumin or somatostatin but not calretinin. The transcription factors Lhx6 and Sox6 play critical roles in the specification, migration, and maturation of parvalbumin and somatostatin neurons, but not calretinin neurons, and continue to be strongly expressed in this cell type-specific manner in the prefrontal cortex of adult humans. The authors investigated whether Lhx6 and/or Sox6 mRNA levels are deficient in schizophrenia, which may contribute to cell type-specific disturbances in cortical parvalbumin and somatostatin neurons.

Method

The authors used quantitative PCR and in situ hybridization with film and grain counting analyses to qua

SUBMITTER: Volk DW 

PROVIDER: S-EPMC3513625 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature