Ontology highlight
ABSTRACT:
SUBMITTER: Chen XF
PROVIDER: S-EPMC3513640 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Cell reports 20121121 5
A key feature of RNA polymerase II (Pol II) preinitiation complexes (PICs) is their ability to coordinate transcription initiation with chromatin modification and remodeling. To understand how this coordination is achieved, we employed extensive proteomic and mechanistic analyses to study the composition and assembly of PICs in HeLa cell and mouse embryonic stem cell (ESC) nuclear extracts. Strikingly, most of the machinery that is necessary for transcription initiation on chromatin is part of t ...[more]